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KMID : 1098420200280010021
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Korean Journal of Medicinal Crop Science
2020 Volume.28 No. 1 p.21 ~ p.28
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α-Glucosidase Inhibitory Activity of the Ethanol Extract of Peanut (Arachis hypogaea L.) Skin
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Ha Tae-Joung
Lee Myoung-Hee
Oh Eun-Young
Kim Jung-In
Song Seok-Bo
Kwak Do-Yeon
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Abstract
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Background: Owing to its high efficiency in lipid and protein production, peanut (Arachis hypogaea L.) is considered one of most important crops world-wide. The kernels of peanuts are undoubtedly the most important product this plant, whereas the skin is almost completely neglected in nutraceutical terms. However, peanut skin contains potentially health-promoting phenolics and dietary fiber, and there is considerable potential for commercial exploitation. In this study, we evaluated the α-glucosidase inhibitory activity of an extract of peanut skin (PS).
Methods and Results: The α-glucosidase inhibitory effects of 80% ethanol extracts of peanut (A.
hypogaea L. ‘Sinpalkwang’) skin were evaluated and found to have a half-maximal inhibitory concentration (IC50) value of 1.2 ㎍/㎖. Progress curves for enzyme reactions were recorded spectrophotometrically, and the inhibition kinetics revealed time-dependent inhibition with enzyme isomerization. Furthermore, using ultra-high performance liquid chromatography combined with quadrupole-orbitrap mass spectrometry, we identified 26 compounds in the peanut skin extract, namely, catechin, epicatechin, and 24 proanthocyanidins.
Conclusions: The results suggest that peanut skin can be utilized as an effective source of α-glucosidase inhibition in functional foods and nutraceuticals.
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KEYWORD
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Arachis hypogaes, α-Glucosidase, Peanut Skin, Proanthocyanidin, Time-dependent Inhibition
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